Dopamine D2 receptor knockout mice develop features of Parkinson disease
Identifieur interne : 000B10 ( Main/Exploration ); précédent : 000B09; suivant : 000B11Dopamine D2 receptor knockout mice develop features of Parkinson disease
Auteurs : Rogan B. Tinsley [Australie] ; Chris R. Bye [Australie] ; Clare L. Parish [Australie] ; Angela Tziotis-Vais [Australie] ; Sonia George [Australie] ; Janetta G. Culvenor [Australie] ; Qiao-Xin Li [Australie] ; Colin L. Masters [Australie] ; David I. Finkelstein [Australie] ; Malcolm K. Horne [Australie]Source :
- Annals of Neurology [ 0364-5134 ] ; 2009-10.
Abstract
Objective: This study questions whether increased dopamine (DA) turnover in nigral neurons leads to formation of Lewy bodies (LBs), the characteristic α‐synuclein–containing cytoplasmic inclusion of Parkinson disease (PD). Methods: Mice with targeted deletion of the dopamine D2 receptor gene (D2R[−/−]) have higher striatal and nigral dopamine turnover and elevated oxidative stress. These mice were examined for evidence of histological, biochemical, and gene expression changes consistent with a synucleinopathy. Results: LB‐like cytoplasmic inclusions containing α‐synuclein and ubiquitin were present in substantia nigra pars compacta (SNpc) neurons of older D2R(−/−) mice, and were also occasionally seen in aged wild‐type mice. These inclusions displaced the nucleus of affected cells and were eosinophilic. Diffuse cytosolic α‐synuclein immunoreactivity in SNpc neurons increased with age in both wild‐type and D2R(−/−) mice, most likely because of redistribution of α‐synuclein from striatal terminals to SNpc cell bodies. Gene and protein expression studies indicated endoplasmic reticulum (ER) stress and changes in trafficking and autophagic pathways in D2R(−/−) SNpc. These changes were accompanied by a loss of DA terminals in the dorsal striatum, although there was no evidence of progressive cell death in the SNpc. Interpretation: Increased sprouting and DA turnover, as observed in PD and D2R(−/−) mice, augments LB‐like inclusions and axonal degeneration of dopaminergic neurons. These changes are associated with ER stress and autophagy. Ann Neurol 2009;66:472–484
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DOI: 10.1002/ana.21716
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Culvenor</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, the University of Melbourne, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Neuroscience, the University of Melbourne, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qiao In" sort="Li, Qiao In" uniqKey="Li Q" first="Qiao-Xin" last="Li">Qiao-Xin Li</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, the University of Melbourne, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Neuroscience, the University of Melbourne, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. 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Methods: Mice with targeted deletion of the dopamine D2 receptor gene (D2R[−/−]) have higher striatal and nigral dopamine turnover and elevated oxidative stress. These mice were examined for evidence of histological, biochemical, and gene expression changes consistent with a synucleinopathy. Results: LB‐like cytoplasmic inclusions containing α‐synuclein and ubiquitin were present in substantia nigra pars compacta (SNpc) neurons of older D2R(−/−) mice, and were also occasionally seen in aged wild‐type mice. These inclusions displaced the nucleus of affected cells and were eosinophilic. Diffuse cytosolic α‐synuclein immunoreactivity in SNpc neurons increased with age in both wild‐type and D2R(−/−) mice, most likely because of redistribution of α‐synuclein from striatal terminals to SNpc cell bodies. Gene and protein expression studies indicated endoplasmic reticulum (ER) stress and changes in trafficking and autophagic pathways in D2R(−/−) SNpc. These changes were accompanied by a loss of DA terminals in the dorsal striatum, although there was no evidence of progressive cell death in the SNpc. Interpretation: Increased sprouting and DA turnover, as observed in PD and D2R(−/−) mice, augments LB‐like inclusions and axonal degeneration of dopaminergic neurons. These changes are associated with ER stress and autophagy. Ann Neurol 2009;66:472–484</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Tinsley, Rogan B" sort="Tinsley, Rogan B" uniqKey="Tinsley R" first="Rogan B." last="Tinsley">Rogan B. Tinsley</name></noRegion><name sortKey="Bye, Chris R" sort="Bye, Chris R" uniqKey="Bye C" first="Chris R." last="Bye">Chris R. Bye</name><name sortKey="Culvenor, Janetta G" sort="Culvenor, Janetta G" uniqKey="Culvenor J" first="Janetta G." last="Culvenor">Janetta G. Culvenor</name><name sortKey="Culvenor, Janetta G" sort="Culvenor, Janetta G" uniqKey="Culvenor J" first="Janetta G." last="Culvenor">Janetta G. Culvenor</name><name sortKey="Finkelstein, David I" sort="Finkelstein, David I" uniqKey="Finkelstein D" first="David I." last="Finkelstein">David I. Finkelstein</name><name sortKey="George, Sonia" sort="George, Sonia" uniqKey="George S" first="Sonia" last="George">Sonia George</name><name sortKey="George, Sonia" sort="George, Sonia" uniqKey="George S" first="Sonia" last="George">Sonia George</name><name sortKey="George, Sonia" sort="George, Sonia" uniqKey="George S" first="Sonia" last="George">Sonia George</name><name sortKey="Horne, Malcolm K" sort="Horne, Malcolm K" uniqKey="Horne M" first="Malcolm K." last="Horne">Malcolm K. Horne</name><name sortKey="Horne, Malcolm K" sort="Horne, Malcolm K" uniqKey="Horne M" first="Malcolm K." last="Horne">Malcolm K. Horne</name><name sortKey="Horne, Malcolm K" sort="Horne, Malcolm K" uniqKey="Horne M" first="Malcolm K." last="Horne">Malcolm K. Horne</name><name sortKey="Li, Qiao In" sort="Li, Qiao In" uniqKey="Li Q" first="Qiao-Xin" last="Li">Qiao-Xin Li</name><name sortKey="Li, Qiao In" sort="Li, Qiao In" uniqKey="Li Q" first="Qiao-Xin" last="Li">Qiao-Xin Li</name><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name><name sortKey="Parish, Clare L" sort="Parish, Clare L" uniqKey="Parish C" first="Clare L." last="Parish">Clare L. Parish</name><name sortKey="Tziotis Ais, Angela" sort="Tziotis Ais, Angela" uniqKey="Tziotis Ais A" first="Angela" last="Tziotis-Vais">Angela Tziotis-Vais</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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